Article

A sulfur-free peptide mimic of surfactant protein B (B-YL) exhibits high in vitro and in vivo surface activities

2018-07-10

Abstract excerpt

<h4>Background: </h4> : Animal-derived surfactants containing surfactant proteins B (SP-B) and C (SP-C) are used to treat respiratory distress syndrome (RDS) in preterm infants. SP-B (79 residues) plays a pivotal role in lung function and the design of synthetic lung surfactant. Super Mini-B (SMB), a 41-residue peptide based on the N- and C-domains of SP-B covalently joined with a turn and two disulfides, folds as...

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Literature Corpus work: d6f5aa16-044e-5d7d-a0c2-cd96b4323f95
DOI: 10.12688/gatesopenres.12799.2

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