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Age-related Macular Degeneration patient deep phenotyping and whole genome sequencing analysis identifies coding variants linking small low-luminance visual deficit to fat storage defects

2022-06-26

Abstract excerpt

<h4>Background</h4> The basis of Age-related macular degeneration (AMD) genetic risk has been well documented; however, few studies have looked at genetic biomarkers of disease progression or treatment response within advanced AMD patients. Here we report the first genome-wide analysis of genetic determinants of low-luminance vision deficit (LLD), which is seen as predictive of visual acuity loss and anti-VEGF tr...

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Literature Corpus work
d6e5812b-31bc-5caa-84c9-8e0a12074511
DOI
10.1101/2022.06.22.497149
Open publication

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Age-related Macular Degeneration patient deep phenotyping and whole genome sequencing analysis identifies coding variants linking small low-luminance visual deficit to fat storage defectsDOI 10.1101/2022.06.22.497149
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