Article

Concomitant L248V with E225V mutation in BCR-ABL gene associated with rapid CML lymphoid blast crisis

2024-03-26

Abstract excerpt

<title>Abstract</title> <p>Background Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome (Ph), resulting from the t(9;22)(q34;q11.2) translocation. Imatinib, a tyrosine kinase inhibitor, has revolutionized the treatment of CML. However, despite the initial response, some patients may progress to an advanced stage, such as a blast crisis. C...

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Literature Corpus work: d6cf8724-eddc-5695-bd9a-33efebdcf2fe
DOI: 10.21203/rs.3.rs-4148236/v1

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