Article

Cholinergic Signaling Modulates Intestinal Pathophysiology in a <i>Drosophila</i> Model of Cystic Fibrosis

2025-07-05

Abstract excerpt

Cystic fibrosis (CF) is a monogenic genetic disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride/bicarbonate channel, which is expressed in certain epithelial cells. Current therapies focus on restoring CFTR function, but many gut-related pathologies persist, highlighting the need for complementary treatments to improve the quality of life of people with CF. In thi...

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Literature Corpus work: d6bb813b-be8e-5379-9fcf-01702820e8c5
DOI: 10.1101/2025.07.02.662792

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