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Article

Cholinergic signaling modulates intestinal pathophysiology in a Drosophila model of cystic fibrosis.

PLoS genetics - 1 Feb 2026

Lane Elizabeth A, Petsakou Afroditi, Liu Ying, Chen Weihang, Qadiri Mujeeb, Hu Yanhui, Perrimon Norbert

Abstract excerpt

Cystic fibrosis (CF) is a monogenic genetic disease caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) chloride/bicarbonate channel, which is expressed in certain epithelial cells. Current therapies focus on restoring CFTR function, but many gut-related pathologies persist, highlighting the need for complementary treatments to improve the quality of life of people with CF. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41701793
DOI: 10.1371/journal.pgen.1012048
PMCID: PMC12923121

Genes

CFTR
FOXA1
FOXA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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