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Article

SARS-CoV-2 can infect and propagate in human placenta explants

4 Nov 2021

Abstract excerpt

The ongoing SARS-CoV-2 pandemic continues to lead to high morbidity and mortality. During pregnancy, severe maternal and neonatal outcomes and placental pathological changes have been described. We evaluate SARS-CoV-2 infection at the maternal-fetal interface using precision-cut slices (PCSs) of human placenta. Remarkably, exposure of placenta PCSs to SARS-CoV-2 leads to a full replication cycle with infectious...

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PMID: 34751258
DOI: 10.1016/j.xcrm.2021.100456

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