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Immune checkpoint inhibitors in children with replication-repair-deficient high-grade gliomas. The South London Paediatric & TYA Neuro-Oncology Network experience

2026-03-18

Abstract excerpt

<title>Abstract</title> <p>Purpose High-grade gliomas (HGG) are the most common intracranial tumors in children with replication repair deficiency (RRD) syndromes. Defective DNA repair leads to a high mutational burden, providing biological rationale for immune checkpoint inhibitors (ICI). However, responses to ICI are heterogeneous, and resistance mechanisms remain poorly understood. We report on the experience...

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Literature Corpus work
3b3801c3-6d75-56be-9a91-1c553eb6001c
DOI
10.21203/rs.3.rs-9131402/v1
Open publication

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