Article

Exploring the maturation of a monocytic cell line using self-organizing maps of single-cell Raman spectra

2020-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Phorbol myristate acetate (PMA)-differentiated THP-1 cells are routinely used in lieu of primary macrophages to study macrophage polarization during host-pathogen interactions and disease progression. The phenotypes of the THP-1 macrophages are influenced by the level and duration of PMA stimulation, and possibly also by the presence of adhesion factors. Here, we use self-organizing maps (SOMs)...

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Literature Corpus work: d5af14fd-beac-57e9-90df-10b426deb552
DOI: 10.1101/2020.05.30.124552

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