Article

Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway

2022-08-01

Abstract excerpt

<title>Abstract</title> <p>The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8, an endogenous ligand of Toll-like receptor 4 (TLR4), is known as a key molecule in the tumor microenvironment and premetastatic niche formation. We firstly generated a novel multivalent S100A8 competitive inhibitory peptide (divalent peptide3A5) against TLR4/MD-2, using the ala...

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Literature Corpus work: d526e2d1-e1df-5fc4-aafb-6493e0d5c3c7
DOI: 10.21203/rs.3.rs-1882254/v1

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