Article

A novel bivalent anti-c-MET/PD-1 bispecific antibody exhibits potent cytotoxicity against c-MET/PD-L1-positive colorectal cancer

2022-04-08

Abstract excerpt

Previously, we generated a novel bispecific antibody (BsAb) targeting c-MET and PD-1 (PDCD1), which can bridge T cells and c-MET positive tumor cells. This study investigated functional mechanisms and antitumor activities of our BsAb against c-MET/PD-L1 (CD274) positive colorectal cancer (CRC). The Cancer Genome Atlas database was used to evaluate c-MET expression in tumor tissues. The expression of plasma exosoma...

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Literature Corpus work: 250eb969-f579-5c3c-9ec1-2ab32c4350e5
DOI: 10.21203/rs.3.rs-1528415/v1

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