Article

Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20.

2025-07-28

Abstract excerpt

<title>Abstract</title> <p>The Omicron variant of SARS-CoV-2 emerged in late 2021 and since then Omicron subvariants have continued to evolve and dominate globally. The viral S protein evolved towards highly efficient antibody evasion and replicative capacity in the upper respiratory tract resulting in high transmissibility. At the same time, the mutations acquired in the S protein diminish infection of the lung...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d501993b-58d1-5ecc-b114-adc1d1ad4085
DOI: 10.21203/rs.3.rs-7065324/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20.DOI 10.21203/rs.3.rs-7065324/v1Read

Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20Semantic proximity Read

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2Semantic proximity Read

Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionSemantic proximity Read

SARS-CoV-2 and Emerging Variants: Unmasking Structure, Function, Infection, and Immune Escape MechanismsSemantic proximity Read

Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionSemantic proximity Read

SARS-CoV-2 variants show a gradual declining pathogenicity and pro-inflammatory cytokine spur, an increasing antigenic and antiinflammatory cytokine induction, and rising structural protein instabilitySemantic proximity Read

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionSemantic proximity Read

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD bindingSemantic proximity Read

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shiftSemantic proximity Read

Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal CellsSemantic proximity Read

ACE2 partially dictates the host range and tropism of SARS-CoV-2Semantic proximity Read

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variantSemantic proximity Read