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DNA Repair Proteins MCPh1 and BRD4 Expression and Association with Immune Checkpoint Markers in Endometrial Carcinoma

2025-10-28

Abstract excerpt

<h4>Background: </h4> Endometrial carcinoma (EC) is the most common uterine cancer in the USA with rising incidence and mortality rates. Microcephalin 1 (MCPH1) and Bromodomain Containing 4 (BRD4) are DNA repair proteins involved in maintaining genomic stability and chromatin regulation. Dysregulated expression of these genes has been linked to poorer patient outcomes in EC. Immunotherapy, particularly immune chec...

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Literature Corpus work
d3d0a0f3-f489-5515-8cbe-dbc366665a9a
DOI
10.20944/preprints202510.2148.v1
Open publication

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