Article

Significance of nuclear upregulation of LOXL2 in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndrome

2020-02-24

Abstract excerpt

<h4>Background: </h4> Fibrotic scarring is an important prognostic factor for acute respiratory distress syndrome (ARDS). Lysyl oxidase-like 2 (LOXL2), an amine oxidase, is thought to make an integral contribution to fibrotic scarring by facilitating collagen cross-linking. LOXL2 has also been proposed to epigenetically regulate gene expression to direct cell fate. Recent clinical outcomes demonstrated the ineffec...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d381fb9d-71b7-504b-90f2-1f731444cd24
DOI: 10.21203/rs.2.24386/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Significance of nuclear upregulation of LOXL2 in fibroblasts and myofibroblasts in the fibrotic process of acute respiratory distress syndromeDOI 10.21203/rs.2.24386/v1Read

Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosisSemantic proximity Read

Collagen crosslinking and organizational patterns reflect common disease processes in idiopathic pulmonary fibrosis and non-resolving acute respiratory distress syndromeSemantic proximity Read

Gene expression profiles reveal molecular mechanisms involved in the progression and resolution of bleomycin-induced lung fibrosisSemantic proximity Read

BACH1 transcriptionally upregulates FOSL2 to induce M2 macrophages phenotype by activating TGFβ/SMAD signaling to promote the transformation of lung fibroblasts into myofibroblasts.Semantic proximity Read

BCL6 attenuates hyperoxia-induced lung injury by inhibiting NLRP3-mediated inflammation in fetal mouseSemantic proximity Read

PRDX4 regulates AMs cell activity through the AKT/NF-κB pathway to inhibit the progress of pulmonary fibrosisSemantic proximity Read

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitisSemantic proximity Read

Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in FibroblastsSemantic proximity Read

Lysyl oxidase-variant 2 (LOX-v2) colocalizes with promyelocytic leukemia-nuclear bodies in the nucleus.Semantic proximity Read

Lysyl Oxidase Activity Is Dysregulated during Impaired Alveolarization of Mouse and Human LungsSemantic proximity Read

Integrated long non‐coding RNA analyses identify novel regulators of epithelial‐mesenchymal transition in the mouse model of pulmonary fibrosisSemantic proximity Read

rhMFGE8 Attenuates Endothelial-to-Mesenchymal Transition in Acute Lung Injury Induced by Lipopolysaccharide Through the BMP/Smad1/4/5/Snail Signalling PathwaySemantic proximity Read