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Article

A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy.

PloS one - 1 Jan 2018

Jones Takako, Jones Peter L

Abstract excerpt

The Double homeobox 4 (DUX4) gene is an important regulator of early human development and its aberrant expression is causal for facioscapulohumeral muscular dystrophy (FSHD). The DUX4-full length (DUX4-fl) mRNA splice isoform encodes a transcriptional activator; however, DUX4 and its unique DNA binding preferences are specific to old-world primates. Regardless, the somatic cytotoxicity caused by DUX4 expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29415061
DOI: 10.1371/journal.pone.0192657
PMCID: PMC5802938

Genes

DUX4
ACTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A cre-inducible DUX4 transgenic mouse model for investigating facioscapulohumeral muscular dystrophy.PMID 29415061Read ↗

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