Article

Endothelin 3 and T-type Ca <sup>2+</sup> channels drive enteric neural crest cell calcium activity, contractility and migration

2025-10-24

Abstract excerpt

Enteric neural crest cells (ENCCs) colonize the gut during embryogenesis and migration defects give rise to Hirschsprung disease (HD). Mutations in GDNF/RET and EDN3/EDNRB are known to be causal in HD. Here, we show that migrating ENCCs in mice exhibit endogenous EDN3/EDNRB-gated calcium activity, mediated by chloride channels, T-type Ca 2+ channels and inositol trisphosphate-sensitive intracellular-store release...

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Literature Corpus work: d25b906b-3357-5f53-aabc-64a6f244f274
DOI: 10.1101/2025.10.23.684245

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