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Article

Endothelin-3 and T-type Ca2+ channels drive enteric neural crest cell calcium activity, contractility and migration.

Nature communications - 20 Jan 2026

Chevalier Nicolas R, Gayda Fanny, Bondurand Nadège, Chan Ze Chi, Savy Thierry, Frain Monique, El Merhie Amira, Canta Lenuta, Dicu Monica, Le Parco Isabelle, Zig Léna

Abstract excerpt

Enteric neural crest cells (ENCCs) colonize the gut during embryogenesis and migration defects give rise to Hirschsprung disease (HD). Mutations in GDNF/RET and EDN3/EDNRB are known to be causal in HD. Here, we show that migrating ENCCs in mice exhibit endogenous EDN3/EDNRB-gated calcium activity, mediated by chloride channels, T-type Ca2+ channels and inositol trisphosphate-sensitive intracellular-store release....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41559055
DOI: 10.1038/s41467-025-68121-5
PMCID: PMC12876838

Genes

EDN3
EDNRB
CACNA1H
GDNF
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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