Article

A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV-C9ORF72 (G <sub>4</sub> C <sub>2</sub> ) <sub>66</sub> mouse model

2024-08-27

Abstract excerpt

The G 4 C 2 hexanucleotide repeat expansion in C9ORF72 is the major genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Despite considerable efforts, the development of mouse models of C9-ALS/FTD useful for therapeutic development has proven challenging due to the intricate interplay of genetic and molecular factors underlying this neurodegenerative disorder...

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Literature Corpus work: d23a0c53-7b0b-52bb-89e4-d1f0420591dc
DOI: 10.1101/2024.08.27.607409

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