Liver fibrosis negatively impacts in vivo gene transfer to hepatocytes

Abstract excerpt

<title>Abstract</title> <p>Liver fibrosis is a pathological process occurring in several genetic and acquired disease conditions. The fibrosis-related alterations of the liver tissue and hepatic cell metabolism may negatively affect therapeutic approaches targeting the liver. Among these, viral-vector-mediated gene transfer to the liver showed clinical efficacy and safety as a treatment for inherited diseases due...

Topics

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• Cells, Cultured
• Coculture Techniques
• Hepatic Stellate Cells
• Liver physiology and pathology
• RNA Interference and Gene Delivery
• Viral gastroenteritis research and epidemiology
• Viral Infections and Immunology Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

d1ac4d89-2376-5a12-9e58-1f5b1f7b95ba

DOI

10.21203/rs.3.rs-4011604/v1