Article

Inadvertent Transfer of Murine VL30 Retrotransposons to CAR-T Cells

2022-02-01

Abstract excerpt

For more than a decade genetically engineered autologous T-cells have been successfully employed as immunotherapy drugs for patients with incurable blood cancers. The active component in some of these game-changing medicines are autologous T-cells that express viral vector-delivered chimeric antigen receptors (CARs), which specifically target proteins that are preferentially expressed on cancer cells. Some of thes...

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Literature Corpus work: d18cc253-b6dd-5f6e-b3b8-e2e30be921a2
DOI: 10.1101/2022.02.01.478686

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