Article

Genomic Analyses of SLAMF7 CAR-T Cells Manufactured by <i>Sleeping Beauty</i> Transposon Gene Transfer for Immunotherapy of Multiple Myeloma

2019-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Widespread treatment of human diseases with gene therapies necessitates the development of gene transfer vectors that integrate genetic information effectively, safely and economically. Accordingly, significant efforts have been devoted to engineer novel tools that i) achieve high-level stable gene transfer at low toxicity to the host cell; ii) induce low levels of genotoxicity and possess a ‘sa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ebb536c-130c-53c0-9e3b-bbb3356d9137
DOI: 10.1101/675009

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genomic Analyses of SLAMF7 CAR-T Cells Manufactured by <i>Sleeping Beauty</i> Transposon Gene Transfer for Immunotherapy of Multiple MyelomaDOI 10.1101/675009Read

CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myelomaSemantic proximity Read

Transposon-Based CAR T Cells in Acute Leukemias: Where Are We Going?Semantic proximity Read

A new approach to gene therapy using <i>Sleeping Beauty</i> to genetically modify clinical‐grade T cells to target <scp>CD</scp>19Semantic proximity Read

Generation and GMP scale-up of human CAR-T cells using non-viral Sleeping Beauty transposons for B cell malignancesSemantic proximity Read

A meta-analysis on safety and efficacy of CD19 directed CAR T-cells generated using sleeping beauty transposon systemSemantic proximity Read

Automated, scaled, transposon-based production of CAR T cellsSemantic proximity Read

Comparison of Lentiviral and Sleeping Beauty Mediated αβ T Cell Receptor Gene TransferSemantic proximity Read

Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapiesSemantic proximity Read

Nonviral Gene Delivery with the <i>Sleeping Beauty</i> Transposon SystemSemantic proximity Read

Going non-viral: theSleeping Beautytransposon system breaks on through to the clinical sideSemantic proximity Read

Efficient Non-Viral T-Cell Engineering by Sleeping Beauty Minicircles Diminishing DNA Toxicity and miRNAs Silencing the Endogenous T-Cell ReceptorsSemantic proximity Read

Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase SystemSemantic proximity Read