Article

Resistance to anti-orthopoxviral drug tecovirimat (TPOXX<sup>®</sup>) during the 2022 mpox outbreak in the US

2023-05-18

Abstract excerpt

<h4>Background</h4> During the 2022 multinational outbreak of monkeypox virus (MPXV) clade IIb, the antiviral drug tecovirimat (TPOXX ® ) was deployed in the US on a large scale for the first time ever. The MPXV F13L gene homolog encodes the target of tecovirimat, and single amino acid changes in the F13 protein are known to cause resistance to tecovirimat in orthopoxviruses (OPXV). <h4>Methods</h4> Whole genome m...

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Literature Corpus work: 5275a817-ad0a-5bd0-b819-dccdc6958792
DOI: 10.1101/2023.05.16.23289856

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