Article

SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1ɑ and phosphorylated tau

2024-11-23

Abstract excerpt

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to infect the human brain and a subset of human neurons in vitro . We have previously demonstrated that the virus enters the human induced pluripotent stem cell (hiPSC)-derived neurons via an endosomal-lysosomal pathway, which is dependent on low levels of angiotensin-converting enzyme 2 (ACE2) and independent of transmembrane serine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d134a8e0-04b3-5a3a-bba8-13df2ab7c6f0
DOI: 10.1101/2024.11.21.624622

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1ɑ and phosphorylated tauDOI 10.1101/2024.11.21.624622Read

SARS-CoV-2 infection of human neurons requires endosomal cell entry and can be blocked by inhibitors of host phosphoinositol-5 kinaseSemantic proximity Read

SARS-CoV-2 infects neurons, astrocytes, choroid plexus epithelial cells and pericytes of the human central nervous systemSemantic proximity Read

Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neuronsSemantic proximity Read

SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic PathwaysSemantic proximity Read

Poor sensitivity of iPSC-derived neural progenitors and glutamatergic neurons to SARS-CoV-2Semantic proximity Read

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 NeurotropismSemantic proximity Read

SARS-CoV2 infection triggers inflammatory conditions and astrogliosis-related gene expression in long-term human cortical organoidsSemantic proximity Read

Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic miceSemantic proximity Read

Proteomic Analysis of Endemic Viral Infections in Neurons offers Insights into Neurodegenerative DiseasesSemantic proximity Read

SARS-CoV-2 infection leads to Tau pathological signature in neuronsSemantic proximity Read

Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral OrganoidsSemantic proximity Read

Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disordersSemantic proximity Read