Article

Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons

2022-11-18

Abstract excerpt

Severe acute respiratory coronavirus 2 (SARS-CoV-2) infection causes neurological disease in some patients suggesting that infection can affect both the peripheral and central nervous system (PNS and CNS, respectively). It is not clear whether the outcome of SARS-CoV-2 infection of PNS and CNS neurons is similar, and which are the key factors that cause neurological disease: SARS-CoV-2 infection or the subsequent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c578a23f-5741-5d57-af7a-ae34713fd01e
DOI: 10.1101/2022.11.18.517047

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neuronsDOI 10.1101/2022.11.18.517047Read

SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic PathwaysSemantic proximity Read

Poor sensitivity of iPSC-derived neural progenitors and glutamatergic neurons to SARS-CoV-2Semantic proximity Read

SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1ɑ and phosphorylated tauSemantic proximity Read

SARS-CoV-2 Infection Causes Dopaminergic Neuron SenescenceSemantic proximity Read

Expression of ACE2 and a viral virulence-regulating factor CCN family member 1 in human iPSC-derived neural cells: implications for COVID-19-related CNS disordersSemantic proximity Read

SARS-CoV-2 infection causes dopaminergic neuron senescenceSemantic proximity Read

Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2 strain WA1/2020 as well as variants delta and omicronSemantic proximity Read

SARS-CoV-2 Infects Peripheral Sensory Neurons and Promotes Axonal Degeneration via TRPV1 ActivationSemantic proximity Read

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 NeurotropismSemantic proximity Read

SARS-CoV-2 infection of human neurons requires endosomal cell entry and can be blocked by inhibitors of host phosphoinositol-5 kinaseSemantic proximity Read

Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral OrganoidsSemantic proximity Read

Cerebral Organoids Derived from a Parkinson’s Patient Exhibit Unique Pathogenesis from Chikungunya Virus Infection when Compared to a Non-Parkinson’s PatientSemantic proximity Read