Article

Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense Mediated Decay as Modifiers of ALS <i>C9orf72</i> Toxicity

2019-06-21

Abstract excerpt

<h4>SUMMARY</h4> The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a hexanucleotide repeat expansion in C9orf72 (C9-HRE). While RNA and dipeptide repeats produced by the C9-HRE disrupt nucleocytoplasmic transport, the proteins that become redistributed remain unknown. Here, we utilized subcellular fractionation coupled with tandem mass spectrometry and iden...

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Literature Corpus work: d119e003-bb77-5b32-b229-231b3ca28949
DOI: 10.1101/677419

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