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Ex vivo human leukemia blood model illustrates limitations of cancer-targeting PEGylated nanoparticles

2024-05-31

Abstract excerpt

Antibody-directed targeting of chemotherapeutic nanomaterials to primary human cancers could improve efficacy and reduce off-target toxicities. We developed an ex vivo model to study the targeting of primary human Chronic Lymphocytic Leukemia (CLL) in whole blood samples from 15 subjects with CLL. Anti-CD20 targeted polyethylene glycol (PEG)-based nanoparticles had generally efficient targeting of CLL cells and lo...

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Literature Corpus work
d0b08e35-0352-5ac6-9005-4741f6bb8cf9
DOI
10.1101/2024.05.29.24308091
Open publication

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Ex vivo human leukemia blood model illustrates limitations of cancer-targeting PEGylated nanoparticlesDOI 10.1101/2024.05.29.24308091
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