Article

Human ventromedial prefrontal cortex lesions enhance expectation-related pain modulation

2021-12-01

Abstract excerpt

Pain is strongly modulated by expectations and beliefs. Research across species indicates that subregions of the ventromedial prefrontal cortex (VMPFC) play a fundamental role in learning and generating predictions about valued outcomes. Consistent with this overarching framework, neuroimaging studies of experimental pain indicate that VMPFC activation tracks expectations of pain relief and statistically mediates...

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Literature Corpus work: d0656123-5f0d-546d-8227-a715dea08cee
DOI: 10.1101/2021.11.30.470579

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