Article

Layer-specific cortical processing dissociates sensory and cognitive influences on pain

2026-05-14

Abstract excerpt

Pain arises from the integration of nociceptive input with cognitive and affective processes, yet how these signals are organized within cortical circuits remains unclear. Here, using submillimeter-resolution 7T fMRI, we tested whether bottom-up (BU) and top-down (TD) influences on pain are segregated across cortical layers in human sensory-discriminative regions. Participants underwent a factorial manipulation of...

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Literature Corpus work: 20f9863a-9abf-5c35-bb96-a79f7fe23f1c
DOI: 10.64898/2026.05.12.724526

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