Article

Small-molecule inhibitor of C-terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells

2024-12-17

Abstract excerpt

<h4>Background</h4> A major obstacle for the successful treatment of cancer is the primary presence or development of resistance mechanisms toward therapeutic intervention. In urothelial cancer, cisplatin-based regimens are still routinely employed, and multiple cellular pathways contribute to chemoresistance. Since the identification of heat shock protein 90 (HSP90) as potential cancer target, various HSP90 inhi...

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Literature Corpus work: d046be8f-7392-5d0c-a918-20dd6889e947
DOI: 10.1101/2024.12.16.628644

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