Article

The EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8⁺ T-cell revitalization

2024-10-15

Abstract excerpt

Persistent HIV reservoirs in CD4⁺ T-cells pose a barrier to curing HIV infection. We identified overexpression of enhancer of zeste homolog 2 (EZH2) in HIV-infected CD4⁺ T- cells that survive cytotoxic T lymphocyte (CTL) exposure, suggesting a mechanism of CTL resistance. Inhibition of EZH2 with the FDA-approved drug tazemetostat increased surface expression of major histocompatibility complex class I (MHC-I) on C...

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Literature Corpus work: cff6e64f-fbbd-54ee-a1b6-0b6e3e3eb896
DOI: 10.1101/2024.10.11.617869

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