Article

GLP-1 Refractory Obesity Is Associated with Inferior Weight Loss After Bariatric Surgery and a Distinct Hepatic Mitochondrial Phenotype

2026-08-06

Abstract excerpt

<h4>Background</h4> Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are first-line pharmacotherapy for obesity and metabolic dysfunction-associated steatotic liver disease (MASLD); however, 20–35% of patients fail to achieve clinically meaningful weight loss despite guideline-directed therapy. Whether this GLP-1 refractory obesity (GRO) phenotype is associated with distinct hepatic molecular abnormalities o...

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Literature Corpus work: cfd26481-6e19-5401-bc27-412f36642bbd
DOI: 10.64898/2026.08.04.26359613

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