Back to search

Article

Docking of Velpatasvir to the SARS-CoV-2 Viral Spike Protein-Human ACE2 Complex: repurposing for COVID-19

2021-10-26

Abstract excerpt

<title>Abstract</title> <p>The SARS-CoV-2 outbreak has challenged the world health community and is still out of control. Since there is no clinical drug available for the corona virus therefore the most important and the fastest way of medicines development is to find potential molecules from the marketed drugs. Herein, bioinformatics analysis on the spike protein (S) of CoV and human angiotensin receptor 2 (ACE...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
cfc3212d-9a52-557b-a2d9-6fab2c737b3e
DOI
10.21203/rs.3.rs-1013200/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Docking of Velpatasvir to the SARS-CoV-2 Viral Spike Protein-Human ACE2 Complex: repurposing for COVID-19DOI 10.21203/rs.3.rs-1013200/v1
Drug Repurposing for Covid-19: Discovery of Potential Small-Molecule Inhibitors of Spike Protein-ACE2 Receptor Interaction Through Virtual Screening and Consensus ScoringSemantic proximity
Molecular docking studies of Indian variants of pathophysiological proteins of SARS-CoV-2 with selected drug candidates.Semantic proximity
Protein structure analysis of the interactions between SARS-CoV-2 spike protein and the human ACE2 receptor: from conformational changes to novel neutralizing antibodiesSemantic proximity
Identification of potential inhibitors of SARS-CoV-2 S protein–ACE2 interaction by in silico drug repurposingSemantic proximity
In silico screening of known small molecules to bind ACE2 specific RBD on Spike glycoprotein of SARS-CoV-2 for repurposing against COVID-19Semantic proximity
Elucidating the role of N440K mutation in SARS-CoV-2 spike - ACE-2 binding affinity and COVID-19 severity by virtual screening, molecular docking and dynamics approach.Semantic proximity
Interaction of Drug Candidates with Various SARS-CoV‑2 Receptors: An in Silico Study to Combat COVID-19Semantic proximity
Modeling SARS-CoV-2 spike/ACE2 protein–protein interactions for predicting the binding affinity of new spike variants for ACE2, and novel ACE2 structurally related human protein targets, for COVID-19 handling in the 3PM contextSemantic proximity
Identification of a druggable binding pocket in the spike protein reveals a key site for existing drugs potentially capable of combating Covid-19 infectivitySemantic proximity
Investigation of Critical Binding Pattern in SARS-CoV-2 Spike Glycoprotein with Angiotensin-Converting Enzyme 2: An in Silico Analysis&nbsp;Semantic proximity
Phylogenetic analysis and In silico Screening of drug targets for ACE2 in Human and Spike Glycoprotein in Sars-CoV-2 for control of COVID19Semantic proximity
A new proposed mechanism of some known drugs targeting the SARS-CoV-2 spike glycoprotein using molecular dockingSemantic proximity
Select a neighboring publication to make it the new centre.