Article

Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

2019-05-08

Abstract excerpt

Epithelial homeostasis and regeneration require a pool of quiescent cells. How the quiescent cells are established and maintained is poorly understood. Here we report that Trpv6, a cation channel responsible for epithelial Ca 2+ absorption, functions as a key regulator of cellular quiescence. Genetic deletion and pharmacological blockade of Trpv6 promoted zebrafish epithelial cells to exit from quiescence and re-...

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Literature Corpus work: cf0f927e-ebbc-5218-ac97-78d60043e78d
DOI: 10.1101/631861

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