Article
TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes.
The Journal of biological chemistry - 3 Aug 2007
Lehen'kyi V'yacheslav, Beck Benjamin, Polakowska Renata, Charveron Maria, Bordat Pascal, Skryma Roman, Prevarskaya Natalia
Abstract excerpt
Ca(2+) is an essential factor inducing keratinocyte differentiation due to the natural Ca(2+) gradient in the skin. However, the membrane mechanisms that mediate calcium entry and trigger keratinocyte differentiation had not previously been elucidated. In this study we demonstrate that Ca(2+)-ind...
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