Article
Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patients.
PloS one - 1 Jan 2022
Wong Shukmei, Ehrhart E J, Stewart Samuel, Zismann Victoria, Cawley Jacob, Halperin Rebecca, Briones Natalia, Richter Keith, Sivaprakasam Karthigayini, Perdigones Nieves, Contente-Cuomo Tania, Facista Salvatore, Trent Jeffrey M, Murtaza Muhammed, Khanna Chand, Hendricks William P D
Abstract excerpt
Cancer genomic heterogeneity presents significant challenges for understanding oncogenic processes and for cancer's clinical management. Variation in driver mutation frequency between patients with the same tumor type as well as within an individual patients' cancer can shape the use of mutations as diagnostic, prognostic, and predictive biomarkers. We have characterized genomic heterogeneity between and within...
Topics
- Animals
- Dog Diseases
- Dogs
- Genomics
- Hemangiosarcoma
- Humans
- Mutation
- Prospective Studies
- Splenic Neoplasms
- Exome Sequencing