Article

The role of BFGF-related transcriptional regulation and alternative polyadenylation in calcification model of valve interstitial cells induced by osteoblastic medium

2023-03-28

Abstract excerpt

<h4>Objective: </h4> Calcific aortic valve disease (CAVD) is a major cause of aortic stenosis resulting in angina, heart failure, and death. However, the molecular mechanism of its progression, especially the sophisticated disease-related transcriptional regulation machinery remains to be further elucidated. Methods This study was modeled on porcine valvular interstitial cells (PVIC). We used OIM to induce calcif...

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Literature Corpus work: ce0e11d3-d2cb-5a0a-8355-9b81eeef04db
DOI: 10.21203/rs.3.rs-2674975/v1

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