Article

Postmortem Evaluation of Topoisomerase IIβ, Nurr1, and Neuroinflammatory Signatures in Parkinson's Disease

2026-03-27

Abstract excerpt

<title>Abstract</title> <p>The selective vulnerability of dopaminergic neurons in the substantia nigra pars compacta is a major mystery in the pathogenesis of Parkinson's disease (PD). A growing body of evidence points to the fact that the neurodegenerative process is a result of a complicated interaction between transcriptional dysregulation and chronic neuroinflammation. This study specifically investigates thr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cdfec185-6f67-54b9-b836-361ac98ac6e2
DOI: 10.21203/rs.3.rs-8872745/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Postmortem Evaluation of Topoisomerase IIβ, Nurr1, and Neuroinflammatory Signatures in Parkinson's DiseaseDOI 10.21203/rs.3.rs-8872745/v1Read

A53T α-Synuclein Expression is Associated with Altered Dopaminergic-Like Differentiation and Reduced DNA Topoisomerase IIβ Levels in an In Vitro Model of Parkinson's Disease.Semantic proximity Read

Cellular Model of Alzheimer's Disease: Aβ1-42 Peptide Induces Amyloid Deposition and a Decrease in Topo Isomerase IIβ and Nurr1 ExpressionSemantic proximity Read

Poly(ADP-ribose)polymerase-1 hyperactivation in neurodegenerative diseases: The death knell tolls for neuronsSemantic proximity Read

Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative DisordersSemantic proximity Read

COVID-19 and Parkinson’s Disease: Shared Inflammatory Pathways Under Oxidative StressSemantic proximity Read

Investigating How Inflammation Involving NF-κB Signaling Disrupts the Genetic Architecture of Neurons/Neural Stem Cells and Fuels NeurodegenerationSemantic proximity Read

Identification of the Transcription Factors of CD200R1 and Its Potential Roles in Parkinson’s DiseaseSemantic proximity Read

Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB)- a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's DiseaseSemantic proximity Read

Interplay Between Retroviral Element De-repression and Wnt/β-Catenin Pathway in Cellular Models of Parkinson’s DiseaseSemantic proximity Read

Polymerase I as a Target for Treating Neurodegenerative DisordersSemantic proximity Read

Repressor Element-1 Binding Transcription Factor (REST) as a Possible Epigenetic Regulator of Neurodegeneration and MicroRNA-Based Therapeutic StrategiesSemantic proximity Read

Polymerase I as a Target for Treating Neurodegenerative DisordersSemantic proximity Read