Article

Inhibition of cyclin D1 by new biguanide 4C increases the sensitivity of proficient homologous recombination repair bladder cancer cells to Olaparib via causing G0 / G1 arrest

2024-04-02

Abstract excerpt

<h4>Background: </h4> Results from recent clinical trials do not support PARP inhibitors as monotherapy in urological tumor. Interestingly, biguanides inhibiting homologous recombination repair (HRR) are thought to increase the sensitivity of proficient HRR (HRR-proficient) cancers to Olaparib, but the mechanism of which is not yet clear. New biguanide derivative 4C in our laboratory inhibited significantly prolif...

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Literature Corpus work: cd58850c-35eb-5b5a-9512-511b027f1f7a
DOI: 10.21203/rs.3.rs-4180798/v1

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