Article

MicroRNA320e augments the synthetic lethality of olaparib by regulating homologous recombination repair via PI3K-AKT-mTOR pathway

2024-01-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> With the increase of drug resistance in ovarian cancer(OC), poly ADP-ribose polymerase inhibitors (PARPi) for the treatment of homologous recombination repair defects (HRD) have faced new challenges. MicroRNA320e (miR-320e) plays a negative regulatory role in the progression of many cancers. Therefore, we overexpressed miR-320e in both A2780 cells with HRD and S...

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Literature Corpus work: 4439e7fa-dad1-5d83-9eb2-f3e12eca0404
DOI: 10.21203/rs.3.rs-3849402/v1

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