Article

CB-5083 and luteolin synergistically induce apoptosis of bladder cancer cells via multiple mechanisms

2023-08-23

Abstract excerpt

<h4>Purpose: </h4> Bladder cancer (BC) is a common urological malignancy that still lacks of effective treatments. In recent years, valosin-containing protein (VCP) was emerging as potential target for the treatment of cancers. CB-5083 was a VCP inhibitor that has been evaluated in phase I clinical trials. However, drug-resistance and severe side effects hamper the application of CB-5083. Amounting evidence sugges...

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Literature Corpus work: 6c695433-23d2-5c43-98b3-21d906b924ae
DOI: 10.21203/rs.3.rs-3270847/v1

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