Article

Dioxin Disrupts Thyroid Hormone and Glucocorticoid Induction of <i>klf9</i> , a Master Regulator of Frog Metamorphosis

2021-12-01

Abstract excerpt

Frog metamorphosis, the development of an air-breathing froglet from an aquatic tadpole, is controlled by thyroid hormone (TH) and glucocorticoids (GC). Metamorphosis is susceptible to disruption by 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD), an aryl hydrocarbon receptor (AHR) agonist. Krüppel-Like Factor 9 ( klf9 ), an immediate early gene in the endocrine-controlled cascade of expression changes governing me...

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Literature Corpus work: ccca7569-c45f-5e3f-9539-a10078754ff6
DOI: 10.1101/2021.12.01.470809

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