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Article

A CRISPR-Cas9 mutation in sox9b long intergenic noncoding RNA (slincR) affects zebrafish development, behavior, and regeneration.

Toxicological sciences : an official journal of the Society of Toxicology - 28 Jul 2023

Dasgupta Subham, LaDu Jane K, Garcia Gloria R, Li Sizhen, Tomono-Duval Konoha, Rericha Yvonne, Huang Liang, Tanguay Robyn L

Abstract excerpt

The role of long noncoding RNAs (lncRNAs) regulators of toxicological responses to environmental chemicals is gaining prominence. Previously, our laboratory discovered an lncRNA, sox9b long intergenic noncoding RNA (slincR), that is activated by multiple ligands of aryl hydrocarbon receptor (AHR). Within this study, we designed a CRISPR-Cas9-mediated slincR zebrafish mutant line to better understand its...

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Identifiers

PMID: 37220911
DOI: 10.1093/toxsci/kfad050
PMCID: PMC10375313

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