Article

Discovery of an unusual high number of <i>de novo</i> mutations in sperm of older men using duplex sequencing

2021-04-27

Abstract excerpt

De novo mutations (DNMs) are an important player in heritable diseases and evolution. Of particular interest are highly recurrent DNMs associated with congenital disorders that have been described as selfish mutations expanding in the male germline, thus becoming more frequent with age. Here, we have adapted duplex sequencing (DS), an ultra-deep sequencing method that renders sequence information on both DNA stran...

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Literature Corpus work: ccac17e1-8401-5ca1-93fd-33a2446e87ca
DOI: 10.1101/2021.04.26.441422

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