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Activating mutations in FGFR3 are associated with clonal expansion events and high de novo rates in the male germline

2022-08-03

Abstract excerpt

Delayed fatherhood results in a higher risk to inherit a new germline mutation that might result in a congenital disorder in the offspring. In particular, some FGFR3 mutations increase in frequency with age, but there are still a large number of uncharacterized FGFR3 mutations that could be expanding in the male germline with potentially early or late-onset effects in the offspring. Here, we investigated the mut...

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Literature Corpus work: d6c73d23-4b5f-578e-814e-cd0b75f019ea
DOI: 10.1101/2022.07.31.502216

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Activating mutations in FGFR3 are associated with clonal expansion events and high de novo rates in the male germlineDOI 10.1101/2022.07.31.502216Read

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Activating mutations in FGFR3 are associated with clonal expansion events and high <i>de novo</i> rates in the male germline

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