Article

Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer PDXs

2023-01-24

Abstract excerpt

<h4> A bstract </h4> Patient-derived xenografts (PDXs) are tumour fragments engrafted into mice for preclinical studies. PDXs offer clear advantages over simpler in vitro cancer models - such as cancer cell lines (CCLs) and organoids - in terms of structural complexity, heterogeneity, and stromal interactions. We characterised 231 colorectal cancer PDXs at the genomic, transcriptomic, and epigenetic level and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cca1e1be-19ab-5ed4-abf6-c64f94b99671
DOI: 10.1101/2023.01.24.525314

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative ensemble modelling of cetuximab sensitivity in colorectal cancer PDXsDOI 10.1101/2023.01.24.525314Read

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitorsSemantic proximity Read

XENTURION, a multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients for population-level translational oncologySemantic proximity Read

Modeling colorectal cancer: A bio‐resource of 50 patient‐derived organoid linesSemantic proximity Read

CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical modelsSemantic proximity Read

CMS4-focused multi-omic integration enhances antigen target identification in colorectal cancerSemantic proximity Read

Gene expression biomarkers differentiate overall survival of colorectal cancer upon targeted therapiesSemantic proximity Read

Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine.Semantic proximity Read

Multifocal Organoid Capturing of Colon Cancer Reveals Pervasive Intratumoral Heterogenous Drug ResponsesSemantic proximity Read

“Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction”Semantic proximity Read

Functional precision oncology platform of BRAFV600E-mutated colorectal cancer organoids predicts therapy response and reveals RNF43-mediated immunogenicity.Semantic proximity Read

Colorectal Cancer Patient‐Derived 2D and 3D Models Efficiently Recapitulate Inter‐ and Intratumoral HeterogeneitySemantic proximity Read

Pooled single-cell screen in colorectal cancer defines transcriptional modules linked to oncogenes.Semantic proximity Read