Article

USP7 Inhibition Induces Apoptosis in Glioblastoma by Stabilizing ARF4

2021-06-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Glioblastomas (GBMs) are grade IV central nervous system tumors characterized by a poor prognosis and a median overall survival of 15 months. The glioblastoma cell population is more genetically unstable, resistant to chemotherapy, more angiogenic, and more malignant. Because ubiquitin-specific proteases (USPs) remove ubiquitin from oncogenic protein substrates,...

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Literature Corpus work: cc6bf9bd-268d-56a4-b4e8-0f9c30a7e8a4
DOI: 10.21203/rs.3.rs-552140/v1

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