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Respiratory Chain Complex I Deficiency in Leber Hereditary Optic Neuropathy: Insights from Ophthalmologic and Molecular Investigations in Tunisia

2024-04-24

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<title>Abstract</title> <p>Background <bold>Leber</bold> hereditary optic neuropathy (<bold>LHON</bold>) is a mitochondrial DNA (mtDNA) rare disease due to the mutation of the NADH dehydrogenase enzyme. LHON is characterized by a sudden central vision loss due to focal degeneration of the retinal ganglion cell layer and optic nerve. Symptoms usually appear between the age of 18 and 35 years. Some individuals pre...

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Literature Corpus work: cc4dc755-0123-5eeb-bcb1-270a21936d45
DOI: 10.21203/rs.3.rs-4232944/v1

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