Article

Design-space requirements for abundance-amplified drug-like targeting of RHSVV/PAb240-like p53 exposure in TP53-mutant cancer

2026-05-30

Abstract excerpt

<h4>ABSTRACT</h4> TP53-mutant cancers often accumulate p53 protein, creating a potential abundance-amplified therapeutic target, but wild-type p53 can also rise in stressed normal cells. This study defines the quantitative design requirements for an intracellular strategy targeting RHSVV/PAb240-like conformational exposure of p53 in TP53-mutant/high-p53 cancer. We integrated DepMap cell-line annotations, p53 abun...

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Literature Corpus work: cc2d4e73-1d1f-5db6-b950-00013e937ad7
DOI: 10.64898/2026.05.27.728141

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