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Ire1-triggered <i>hxl1</i> mRNA splicing coordinates stress tolerance and virulence in the pathogenic fungus <i>Trichosporon asahii</i>

2026-06-27

Abstract excerpt

The pathogenic fungus Trichosporon asahii causes severe mycoses in immunocompromised hosts, such as neutropenic patients. In Cryptococcus neoformans , the unfolded protein response (UPR) sensor Ire1 induces hxl1 mRNA splicing and contributes to stress responses and virulence. The function of Ire1-triggered hxl1 mRNA splicing in stress tolerance and virulence of T. asahii , however, remains unclear. Here, we d...

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Literature Corpus work
cc0f7d57-8c11-5c34-a328-fe7d98a6f572
DOI
10.64898/2026.06.27.734954
Open publication

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