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How Do Point Mutations Enhancing the Basic Character of the RBDs of SARS-CoV-2 Variants Affect Their Transmissibility and Infectivity Capacities?

Viruses - 10 Apr 2022

Barre Annick, Klonjkowski Bernard, Benoist Hervé, Rougé Pierre

Abstract excerpt

The spread of SARS-CoV-2 variants in the population depends on their ability to anchor the ACE2 receptor in the host cells. Differences in the electrostatic potentials of the spike protein RBD (electropositive/basic) and ACE2 receptor (electronegative/acidic) play a key role in both the rapprochement and the recognition of the coronavirus by the cell receptors. Accordingly, point mutations that result in an...

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PMID: 35458513
DOI: 10.3390/v14040783
PMCID: PMC9031512

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