Article

Evolutionary exploitation of PD-L1 expression in hormone receptor positive breast cancer

2018-10-26

Abstract excerpt

Based on clinical data from hormone positive breast cancer patients, we determined that there is a potential tradeoff between reducing tumor burden and altering metastatic potential when administering combination therapy of aromatase inhibitors and immune checkpoint inhibitors. While hormone-deprivation therapies serve to reduce tumor size in the neoadjuvant setting pre-surgery, they may induce tumors to change ex...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbce4d9c-057e-5814-90a7-28f84aac9269
DOI: 10.1101/454447

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolutionary exploitation of PD-L1 expression in hormone receptor positive breast cancerDOI 10.1101/454447Read

The immune checkpoint kick start: Optimization of neoadjuvant combination therapy using game theorySemantic proximity Read

Regulatory network and spatial modeling reveal cooperative mechanisms of resistance and immune escape in ER <sub>+</sub> breast cancerSemantic proximity Read

Phenotypic plasticity and competition shape therapy sequencing in HER2+/HER2- breast cancer: A mathematical framework.Semantic proximity Read

A Theoretical Framework for Quantifying Tumour Resistance to Standardized Treatments: A Novel Rudimentary Scalar Mathematical Model with Implications for Breast Cancer Prognosis and TreatmentSemantic proximity Read

Dissecting sources of variability in patient response to targeted therapy: anti-HER2 therapies as a case studySemantic proximity Read

Reconstructing tumor trajectories during therapy through integration of multiple measurement modalitiesSemantic proximity Read

A Mathematical Model of Breast Tumor Progression Based on Immune InfiltrationSemantic proximity Read

LAG3+ CD8+ T cell Subset Drives HR+/HER2− Breast Cancer Reduction in Bispecific Antibody Armed Activated T Cell TherapySemantic proximity Read

Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy EfficacySemantic proximity Read

Intermittent hormonal therapy shows similar outcome than SOC in ER+ breast cancer preclinical modelSemantic proximity Read

Dose Regimen Optimization of PD-L1 Inhibitor and Nab-paclitaxel in Patients with NSCLC: a Quantitative Systems Pharmacology analysisSemantic proximity Read

Examining the Relationship between Pre-Malignant Breast Lesions, Carcinogenesis and Tumor Evolution in the Mammary Epithelium Using an Agent-Based Model.Semantic proximity Read